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Married to Their Research (and Each听Other)

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It鈥檚 complicated. No, it鈥檚 really complicated, and this is not a听movie.

What do you get when you cross a plant biologist鈥檚 lab schedule with a microbiologist鈥檚 experiments? Or mix child-rearing and ? How about having a baby and publishing genomic discoveries?

You get very busy, dedicated people who are devoted to both their home lives and their cutting-edge, potentially world-changing research. You get people who are making it all work despite traveling all over the world, running laboratories, and thinking of ways to save lives and the planet.

Married couples Jorge Rodrigues and Maeli Melotto, Donald Butler and Zeynep Celik-Butler, and C茅dric Feschotte and Ellen Pritham share a glimpse of three approaches to life when beautiful minds meet and听marry.

MAELI MELOTTO AND JORGE RODRIGUES
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Warm, engaging, and passionate about their work and their family, these Brazilian-born biology assistant professors have two kids, two separate research paths, and a collaborative project.

They finish each other鈥檚 sentences in all those arenas, having forged a bond as graduate students in 1990 that has withstood a move from Sao Paulo to Lansing, Mich.; two pregnancies in the midst of postdoctoral research; schedules that can involve 3 a.m. laboratory visits; and necessary global travel, usually one scientist at a听time.

Dr. Melotto studies the secrets of immunity in plants鈥攈ow they defend against bacteria and fungi and how they lose that battle. Her research could lead to non-chemical defenses that could save as much as $500 billion annually in crop听loss.

Dr. Rodrigues focuses on microbes in the Amazon forest and, separately, bug guts鈥攖ermite hindguts, to be听exact.

Though microbes in the forest have a monumental job鈥攔ecycling nutrients so the trees in the world鈥檚 largest ecosystem can use them鈥攕urprisingly little is known about them. Biologists know even less about how they react to deforestation. Rodrigues鈥� work gauging that reaction will provide answers that could influence conservation policy, considering the huge role microbes play in the forest鈥檚 ecology.

His termite work has environmental implications involving ethanol production. Everyone knows termites make short work of wood鈥攖hey process a billion tons of plant matter, or cellulose, every year. But what microbes within the termite鈥檚 gut get that done? The answers could lead to a new means of producing ethanol, since cellulose can be used to make the fuel. Rodrigues is using genome sequencing to address that question.

Besides their research, the couple balance administrative chores, grant writing for funding, and travel to conferences with raising two active, bright, and personable sons ages 10 and 4. They鈥檙e as devoted to family at home as they are to research at work. On a typical Saturday, Maeli prepares a large lunch, their big meal of the day, while Jorge cuddles the younger son. The older boy comes in and out of the kitchen, tasting lunch and giving it his seal of approval.

Jorge is lighthearted and funny by nature but firm when it comes to parenting: 鈥淚f they don鈥檛 like what we鈥檙e having,鈥� he says, 鈥淚 tell them turn on the TV and watch what鈥檚 going on in听Haiti.鈥�

Do the researchers bring work home? Of course. 鈥淲e tend to talk about science all the time,鈥� Jorge says. Is that bad? Not really. 鈥淥ur kids tend to know a lot about science.鈥�

On the other hand, Maeli says, 鈥渙ne wake-up call was when our kids said, 鈥榊ou guys always talk about听work.鈥� 鈥�

When it comes to work, they speak the same language (a spouse outside the field would have a hard time conversing). And the latitude they have as researchers is a bonus. 鈥淲e are able to organize our schedules according to our needs,鈥� Maeli听says.

Jorge laughs. 鈥淚f I need to go to the lab at 3 a.m. and take a culture, Maeli knows I鈥檓 here and not at some听bar.鈥�

ZEYNEP CELIK-BUTLER AND DONALD BUTLER
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A firm boundary between work and home, and an equally firm commitment to not being 鈥渁 package鈥� at work, has been key for these professors.

The Butlers met in the early 1980s as Ph.D. students working under the same thesis adviser at the University of Rochester. Donald had come to Rochester from Toronto, Zeynep from Istanbul. They worked at Southern Methodist University for 15 years before moving to UT Arlington in 2002鈥攍abs, equipment, and听all.

We had a rule we established, the 635 rule. South of Highway 635, we could talk about work. North of Highway 635 is home. We keep it very separate, and that has worked out well for us.
鈥擹eynep Celik-Butler

鈥�We had a rule we established, the 635 rule,鈥� Dr. Celik-Butler says. 鈥淪outh of Highway 635, we could talk about work. North of Highway 635 is home. We keep it very separate, and that has worked out well for us.鈥� Besides, Dr. Butler says, their children 鈥渁re not interested at all.鈥� The older daughter studied chemistry at UT Austin, while the younger is interested in computer graphics.

Even if they were interested, work would be tough for the offspring to understand. The Butlers speak the esoteric language of nanotechnology, the realm of microscopic devices. Theirs is the amazing world of, for example, 鈥渟mart skin鈥� that could soon enable a prosthetic arm to听feel.

Current prosthetic arms generally come with what amounts to a hook or a claw. Celik-Butler, who directs UT Arlington鈥檚 Nanotechnology Research and Teaching Facility, says a few companies have produced more lifelike devices, 鈥渂ut they wound up with a 10-pound arm.鈥�

Nanotechnology can solve that problem, adding the sense of touch with microscopic sensors. The Butlers鈥� 鈥渟mart skin鈥� layers sensors into flexible silicon that could be placed inside a prosthetic arm or听hand.

They have patents for several thin-film infrared detection devices, and some of their work has defense applications. Another device is a small card used with mannequins in cardiopulmonary resuscitation training. It displays red, yellow, and green lights to tell a trainee whether the pushes administered to the patient鈥檚 chest are deep enough and at the right听speed.

The Butlers consciously adopt independent stances at work, even though they collaborate. 鈥淲e have an unspoken rule,鈥� Celik-Butler says. 鈥淚t鈥檚 OK to disagree at听work.鈥�

It鈥檚 important, both scientists say, for their colleagues to know they鈥檙e not going to always share the same opinions.

鈥�My dean commented on how we don鈥檛 even sit together at meetings,鈥� she says. 鈥淲e talk about what other couples talk about, too, except we don鈥檛 talk about it听here.鈥�

ELLEN PRITHAM AND C脡DRIC FESCHOTTE
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At the other end of the spectrum, Drs. Feschotte and Pritham are a team. They publish together. They might stay up four nights in a row working together. Lately they鈥檝e been staying up for a different reason: to care for their infant son.

They grew up an ocean apart. Feschotte was born and educated in France, with a Ph.D. from the University of Paris, while Pritham is a New Hampshire native who earned her Ph.D. at the University of Massachusetts. They met in 2001, doing postdoctoral work at the University of Georgia. Pritham was considering joining a lab in Georgia where Feschotte already worked, and he was asked to show her around.

He鈥檇 been told she was pretty, but 鈥淚 saw her and it was better than I even dreamed,鈥� he says. He decided to show her around a botanical garden, where they 鈥済ot听lost.鈥�

鈥�We went through this one door 15 times,鈥� Pritham recalls. She decided to join the lab, and they married in听2004.

Their studies look within genomes at specific kinds of jumping DNA elements called transposons. The elements move around and replicate. They can cause disease, or they can influence genetic diversity and therefore evolution. Pritham, a biology assistant professor, is looking at their effect on Trichomonas vaginalis, an organism that causes a common sexually transmitted disease, to see how the organism can become more resistant to treatments.

Together they discovered transposons in bats, a breakthrough because they hadn鈥檛 been found before in mammalian genomes. They submitted a manuscript in two weeks, an incredibly short time. (鈥淪candalous!鈥� says Feschotte.)

The birth of their son has curtailed some of their around-the-clock work. But because much of their research is computer-based, they can still be productive from听home.

The couple say they鈥檙e lucky to have strong teams in their听labs.

鈥�We鈥檝e been extremely fortunate in attracting excellent students and postdocs,鈥� Pritham says. And because their son was born at the end of April last year, classes were nearly over, so the first months were less hectic.

The mechanics of child care aside, these positions are more than听jobs.

鈥�Work is not work,鈥� says Feschotte, a associate professor. 鈥淚t鈥檚 our passion.鈥�

Adds Pritham: 鈥淚t鈥檚 not like you can hang up your hat at the end of the day. It鈥檚 a tremendous privilege to be a scientist.鈥�

And to be parents.

鈥�You find room within yourself,鈥� Feschotte says, 鈥渇or that additional love.鈥�

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